While Clayton will no longer contribute to ESPN he will continue with his local radio show on ESPN 710 Seattle.
The network's National Football League coverage has taken previous blows with the departure of Ed Werder, who'd been with ESPN since 1998, and Trent Dilfer, the Super Bowl-winning quarterback who joined the network as an analyst in 2008.
"I am well taken care of by ESPN", he wrote. In 2016, the company cut ties with Cris Carter, Keyshawn Johnson and Ray Lewis.
He joins a laundry list of strong talent to be given their walking papers by the cable television empire, including the likes of Chad Ford, Andy Katz and Ed Werder.
News that Clayton was laid off spread across the internet Wednesday morning before he confirmed the reports to his 1.4 million Twitter followers. It is the end of an era for "The Professor", who had been at the Worldwide Leader for 23 years.
John Clayton, who did most of his live shots from his Seattle-area home studio, appeared in perhaps the most famous satirical "This is SportsCenter" commercial ever.
Since then, names of those affected have dribbled out, with an ESPN source indicating that it was up to laid-off employees to announce their status. Clayton also has a radio show and in 2007 was inducted into the writers' wing of the Pro Football Hall of Fame.
Kunitz's double-OT goal sends Penguins back to Stanley Cup
The victor will face the Nashville Predators, who advanced to the finals for the first time by eliminating Anaheim on Monday. Boucher entered with a 1-1 mark, the last one coming with Tampa in Game 7 of the Eastern Conference final against Boston.
DJI announces the $499 Spark, a compact hand-controlled drone
The two new modes of shooting; Shallow focus and Pano mode make the whole flying experience more enjoyable and interesting too. When it comes time to land, tapping the Spark's "Return to Home" button brings the aircraft back to its departure point.
Mosul residents deny findings of US probe into Iraq strike
Prior to this investigation, the coalition said that at least 352 civilians had been killed since the campaign started. Civil defense personnel search for bodies in the rubble of a building in the Mosul al Jadidah neighborhood of Mosul.